ANÁLISE DOS NÍVEIS DE CORTISOL SALIVAR EM PACIENTES COM ESCLEROSE MÚLTIPLA

Abstract

Introduction: Multiple Sclerosis (MS) is a neurodegenerative autoimmune disease that affects the central nervous system (CNS), with demyelinating characteristics. Due to the phase of adaptations carried out on a daily basis, usually in the afternoon, there is the possibility of an increase in the hormone cortisol, a hormone directly linked to stress and concomitantly worsening the quality of life of patients. An experimental study was carried out, analyzing the afternoon cortisol, using the salivary collection method with the reference value <0.252 µg / dL, in two groups of patients, 40 in the recurrent remitting form (EMRR) and 21 in the primary and secondary progressive form. EMP (EMPP / EMSP) at the Neurology Institute of Curitiba (INC). In conjunction with the saliva collection, a socio-scientific questionnaire was used to characterize the sample and a WHOQL-BREF quality of life questionnaire, in order to observe the quality of life of patients due to stress. Objective: This study aimed to focus on the EMRR and EMP group, which has a low quality of life and altered cortisol levels due to stress, caused by the difficulties caused by the disease and to emphasize the need to monitor cortisol levels. The study was only started after the approval of the Ethics and Research Committee of the INC, under the number 83717718.8.0000.5227.