EFEITOS NEUROPROTETORES RELACIONADO À SUPLEMENTAÇÃO COM CREATINA

Abstract

Creatine is an amino acid compound mainly present in the muscle fibers and brain extremely important in supplying energy for the resynthesis of adenosine triphosphate and intracellular energy deposit. Its properties offer hope for the therapeutic value in processes of neurodegeneration, involving bioenergetic deficit nervous system. The system that involves creatine / phosphocreatine, catalyzed by the enzyme creatine kinase (CK), plays a fundamental role in maintaining the energy balance of the brain. The objective of this review was to elucidate the metabolism of creatine and its possible therapeutic intervention in neurological function, describing some neuropathologies benefited. The material used comprises descriptive articles on the metabolism of the supplement and further experimental studies with animal models serve as a basis to demonstrate the benefit of the creatine in Huntington's Disease, Parkinson's, Alzheimer's and Amyotrophic Lateral Sclerosis (ALS). In conclusion creatine intake associated with Huntington's Disease and Parkinson proved as favorable therapeutic effects resulting in significant neuroprotection. Already on Alzheimer's Disease and ALS creatine did not show improvement in patients. However, more studies should be conducted to highlight then this supplement as a possible therapeutic intervention.